Is ATX-304 Effective for Fat Loss? AMPK Activator Research Guide
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ATX-304 is an AMPK activator, also known as O-304. This synthetic compound may be related to cellular energy balance, and as a metabolic research compound, it is increasingly being studied in the field of metabolism.
Unlike traditional weight management methods, research on ATX-304 focuses primarily on whether it affects mitochondrial function and energy expenditure.
Is ATX-304 effective for fat loss?
Clinical-stage data released by Cambrian Bio show that in obese and prediabetic adults, ATX-304 can induce statistically significant changes in indicators such as resting metabolic rate, hepatic fat, visceral adipose tissue, triglycerides, and adiponectin. Preclinical studies suggest that ATX-304 may reduce body fat content in mice.
The emergence of the topic "ATX-304 fat loss" seems to confirm the current popularity of fat-loss ingredients, as ATX-304-like other metabolic small-molecule compounds currently in the research phase-has not yet been officially approved as a weight-loss treatment by the FDA or other regulatory agencies.
What Is ATX-304?
ATX-304 powder is a compound used in metabolic research in laboratories. Chemical parameters are as follows:
| CAS NO. | 1261289-04-6 |
| MF: | C₁₆H₁₁Cl₂N₃O₂S |
| MW: | 380.25 |
| EINECS: | 202-303-5 |
| Mechanism of action: | AMPK mechanism/AMPK signaling pathway |
| Type: | Research compound |
| Similar Compound: | SLU-PP-915, SLU-PP-332, 5-Amino-1mQ |
Does ATX-304 Reduce Body Fat in Animal Studies?
Yes, a 2025 study published in *JCI Insight* reported that researchers investigated ATX-304 in male C57BL/6J mice fed a choline-deficient high-fat diet (CD-HFD), a model used to study progressive metabolic dysfunction-associated steatotic liver disease (MASLD).
The experimental results showed that ATX-304 research powder may reduce fat mass, improve glucose homeostasis, and potentially reduce oxidative stress. EchoMRI measurements indicated that, following the initial treatment period, mice treated with ATX-304 had food intake approximately 20% to 30% higher than that of untreated mice, while still maintaining a lower body weight.
ATX-304 weight loss vs. Conventional Weight-Loss Mechanisms
Compared to traditional weight-loss mechanisms, as a dual‑target modulator for AMP‑activated protein kinase (AMPK) and mitochondria, ATX‑304 boosts energy consumption and enhances fat breakdown, thereby supporting effective weight loss.
ATX-304 for Research: What Should Buyers Evaluate?
For procurement personnel at pharmaceutical companies, biotech companies, and laboratories looking to purchase ATX-304 research compounds, the following factors should be prioritized when purchasing ATX-304 powder:
1. ATX-304 Chemical Identity
Includes the CAS number, molecular formula, and molecular structure of ATX-304.
2. Purity of ATX-304
Whether the ATX-304 bulk supplier can provide analytical specifications and a Certificate of Analysis (COA) for specific batches as required.
3. Whether the supplier of bulk ATX-304 for laboratory research can provide an HPLC report and analytical data for the product.
4. Whether the ATX-304 manufacturer has bulk supply capability
FAQ
1. What is ATX-304?
The synthetic compound ATX-304 is a small-molecule, orally administered drug with limited peripheral action that is being developed as an AMPK and mitochondrial activator for the treatment of obesity and cardiometabolic diseases.
2. Is ATX-304 Effective for Fat Loss?
Studies have shown that ATX-304 is associated with metabolic fat loss, but it has not been approved by regulatory agencies for use in humans and is currently used only for scientific research.
3. Does ATX-304 work?
Findings from lab research and early clinical studies show ATX‑304 activates the AMPK cellular network. It replicates exercise‑like cellular benefits: revving up metabolism, lowering visceral fat levels, and supporting better blood‑glucose management. Even so, this candidate drug is still under investigation and is not cleared for commercial or public use.
4. Is ATX-304 a peptide?
No, ATX-304 is a small-molecule compound used in metabolic research.
5. Is O-304 the same as ATX-304?
Yes, O-304 is another name for it. The CAS number for this compound is 1261289-04-6.
6. Where can I buy ATX 304?
Jinan Jianfeng Chemical Co., Ltd. is a Chinese pharmaceutical active ingredient company that integrates R&D and production. Synthetic compounds such as ATX-304 (a raw material targeting the AMPK mechanism) and slu-pp915 (targeting the ERRα mechanism) are currently among the most frequently inquired-about products by customers.
If you need O-304, SLU-PP-332 (a research compound), or other metabolic compounds for research purposes, contact us sales01@pharmachemm.com
Related Articles
ATX-304 vs SLU-PP-332: Mechanisms, Research Applications and Key Differences
Where to Buy SLU-PP-915 Powder? Bulk Supplier Guide
SLU-PP-915 VS SLU-PP-332: What are the differences between these pan-err agonists?
Disclaimer:
The information on this website is for communication and learning purposes only and is not medical advice. It should not be used for diagnosing or treating any illness.
Key References
Holm E, Vermeulen I, Parween S, et al. AMPK activator ATX-304 reduces oxidative stress and improves MASLD via metabolic switching. JCI Insight. 2025;10(7).
Cambrian Bio. ATX-304: Obesity and Obesity Associated Diseases Pipeline.
Cambrian Bio. ATX-304 mechanism and clinical development information.
Cambrian Bio. Phase 1b human translational data presented at ADA 86th Scientific Sessions, 2026.
U.S. NIH/NIDDK. Prescription Medications to Treat Overweight & Obesity.
U.S. NIH/NIDDK. Treatment for Overweight & Obesity.
