ATX-304 vs SLU-PP-332: Mechanisms, Research Applications and Key Differences

Aug 14, 2026

Leave a message

Both ATX-304 and SLU-PP-332 are small-molecule synthetic compounds currently used primarily in experimental research. The SLU-PP-332 research compound and the ATX-304 research compound have different research focuses and mechanisms of action.

Of these two metabolic research compounds, SLU-PP-332 is a pan-ERR agonist, while ATX-304 powder is primarily used in research on AMPK activators.

Other pan-ERR agonist: Slu-pp-915

ATX-304 vs SLU-PP-332

Name:	ATX-304/O-304	SLU-PP-332
IUPAC Name:	4-chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]benzamid	4-hydroxy-N-[(E)-naphthalen-2-ylmethylideneamino]benzamide
CAS NO.	1261289-04-6	303760-60-3
MF:	C₁₆H₁₁Cl₂N₃O₂S	C18H14N2O2
MW:	380.25	290.32
EINECS:	202-303-5	218-362-5
InChI:	InChI=1S/C16H11Cl2N3O2S/c17-12-5-1-10(2-6-12)9-21-16(23)20-15(24-21)19-14(22)11-3-7-13(18)8-4-11/h1-8H,9H2,(H,19,20,22,23)	InChI=1S/C18H14N2O2/c21-17-9-7-15(8-10-17)18(22)20-19-12-13-5-6-14-3-1-2-4-16(14)11-13/h1-12,21H,(H,20,22)/b19-12+
Oral Bioavailability:	High oral bioavailability	Improved
Structure:
Primary Target:	AMPK	ERRα/ERRβ/ERRγ
Main Research Area:	Cellular energy metabolism	mitochondrial metabolism research
Regulatory Status:	Not approved by the FDA for human use

What Is ATX-304?

ATX-304, an AMPK activator, is a synthetic small molecule primarily used as an experimental compound in the field of medicinal chemistry research.

Research Areas:

ATX-304 metabolic research

AMPK signaling research

Cellular energy metabolism

Lipid metabolism research

Metabolic switching studies

Mitochondrial and metabolic research

What Is SLU-PP-332?

ASLU-99-332 is a synthetic small molecule that serves as an orally bioavailable ERR agonist.

Research Areas:

Preclinical metabolism research

Skeletal muscle research

Oxidative metabolism studies

Exercise-response signaling research

ATX-304 vs SLU-PP-332: Mechanism Comparison

ATX-304 mechanism

The core mechanism of action of the ATX-304 research compound is to increase glucose utilization and fatty acid oxidation by modulating cellular energy metabolism (through the activation of AMPK), thereby increasing the energy demands of mitochondria and ultimately promoting energy expenditure. Unlike the mechanism of action of the SLU-PP-332 research compound, ATX-304 is a pan-AMPK activator.

SLU-PP-332 mechanism

The core mechanism of action of SLU-PP-332, an ERRα agonist, is not AMPK, but rather the ERR pathway and transcriptional regulation.

ATX-304 Vs SLU-PP-332: Mechanism Comparison

ATX-304 vs SLU-PP-332: Research Applications

Metabolic Research

ATX-304/O-304	SLU-PP-332
AMPK signaling	ERR signaling
lipid metabolism	oxidative metabolism
metabolic switching	mitochondrial function

Exercise and Muscle Research

SLU-PP-332 exerts an "exercise-mimicking" function by targeting estrogen-related receptors (ERRs). In preclinical studies in mice, this compound triggered cellular signaling pathways typically activated by endurance training, thereby promoting metabolism and improving high-intensity endurance running performance.

ATX-304 vs SLU-PP-332: Which Research Compound Should You Choose?

When choosing between ATX-304 and SLU-PP-332, you can make your selection based on the focus of your research area.

1. If your research focuses on AMPK activation or lipid metabolism, ATX-304 is an excellent active ingredient.

2. If your research focuses on exercise-response signaling, ERRα/ERRβ/ERRγ activation, or mitochondrial metabolism, SLU-PP-332 and its structural analog SLU-PP-915 are better choices.

ATX-304 and SLU-PP-332 for Laboratory Research

As with other small-molecule compounds, in laboratory research, factors such as quality and purity can influence the experimental results for SLU-PP-332 powder and ATX-304 powder; various considerations must also be taken into account during procurement.

What Should Researchers Consider When Sourcing These Compounds?

analytical testing, batch consistency, COA, MSDS, HPLC analysis, custom packaging, etc., should all be included in the procurement requirements. Jinan Jianfeng Chemical Co., Ltd. supplies high-quality pure ATX-304 and pure SLU-PP-332. Custom packaging and dosage forms are available.

FAQ

1. What is the difference between ATX-304 and SLU-PP-332?

ATX-304 (O-304) is an AMPK activator, and research focuses on AMPK activation and metabolic switching, while the compound slu-pp-332 is a pan-ERR agonist, and research focuses on ERR activation and oxidative metabolism.

2. Is ATX-304 an AMPK activator?

ATX-304 (O-304) is an AMPK activator primarily used for metabolic switching.

3.Is SLU-PP-332 an ERR agonist?

Both SLU-PP-332 powder and SLU-PP-915 powder are Pan-ERR agonists used in exercise-mimetic research.

4.Does SLU-PP-332 activate ERRα, ERRβ and ERRγ?

SLU-PP-332, a Synthetic Small Molecule, Activates ERRα, ERRβ, and ERRγ.

5. Are ATX-304 and SLU-PP-332 the same type of compound?

They are all small-molecule compounds and are primarily used in research related to metabolism.

6. What are some Pan-ERR agonists?

SLU-99-332 and SLU-PP-915 are the two Pan-ERR agonists currently most commonly purchased on the market.

7.Where can I buy ATX 304?

When selecting a supplier for ATX-304 powder, manufacturers are generally the preferred choice. Jinan Jianfeng Chemical Co., Ltd. is a supplier of research compounds that produces high-quality ATX-304 powder as well as metabolic research compounds such as SLU-99-332 and SLU-PP-915.