ERRα vs AMPK: A Mechanistic Guide to ATX-304, SLU-PP-332, and SLU-PP-915
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ERRα vs. AMPK: Both Are Related to Energy Metabolism-So What Exactly Is the Difference Between Them?
ERRα vs. AMPK: Both Are Related to Energy Metabolism-So What Exactly Sets Them Apart?
In current metabolism-related research, AMPK and ERRα are two of the most extensively studied mechanisms. Unlike ERRα, which regulates the expression of metabolic genes, AMPK functions more like a cellular energy sensor and tends to provide rapid metabolic regulation. The two differ in numerous aspects, including their primary roles and functions as key co-regulators.
What Is AMPK?
AMPK is a key energy sensor in cells and a highly evolutionarily conserved energy-sensing enzyme. When activated, AMPK may reduce energy-consuming processes and increase energy-producing processes. Its core function is the re-regulation of cellular metabolism, rather than simply promoting fat burning. For example, o-304/atx-304 (CAS 1261289-04-6) is an AMPK activator.
What Is ERRα?
ERRα, also known as NR3B1, is an orphan nuclear receptor belonging to the nuclear receptor superfamily. It mediates the relationship between metabolic gene expression and energy demand and plays a crucial role in metabolic research. ERRα is primarily involved in the transcriptional regulation of metabolic pathways. For example, SLU-PP-915 CAS 2285432-92-8 and SLU-PP-332 CAS 303760-60-3 are very typical ERRα agonists.
ERRα vs AMPK: Key Mechanistic Differences
| Comparison Items |
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ERRα |
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Full Name |
AMP-activated protein kinase |
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| Primary role |
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| Type |
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Main Input Signals |
Changes in AMP/ADP/ATP Levels, Energy Stress | Transcriptional co-regulatory networks involving PGC-1α, PGC-1β, and others |
| Primary Mechanisms of Action | Phosphorylates downstream proteins | Binds to DNA and regulates gene expression |
| Research Focus | Energy homeostasis | Mitochondrial & oxidative metabolism |
| Research compound example |
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AMPK and ERRα Are Connected, Not Independent
Previous studies have shown that AMPK activation can influence ERRα expression and ERRα/PGC-1α-related metabolic pathways, and ERRα itself also regulates some AMPK pathway-associated genes.
ATX-304: A Research Compound for AMPK Pathway Studies
ATX-304 CAS 1261289-04-6
ATX-304 bulk research material is a small-molecule compound related to cellular energy metabolism,
| Name | ATX-304 |
| IUPAC Name | 4-chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]benzamid |
| CAS NO | 1261289-04-6 |
| InChI | InChI=1S/C16H11Cl2N3O2S/c17-12-5-1-10(2-6-12)9-21-16(23)20-15(24-21)19-14(22)11-3-7-13(18)8-4-11/h1-8H,9H2,(H,19,20,22,23) |
| Regulatory Status | Not approved by the FDA |
| Response | Relatively rapid |
| Key co-regulator | Multiple signaling proteins |
| Application | AMPK-related research |
SLU-PP-332: An ERR Agonist for Mitochondrial Metabolism Research
SLU-PP-332 CAS 303760-60-3
SLU-PP-332 research compound is an agonist of the estrogen-related receptor (ERR) α, β, and γ nuclear receptors with exercise-mimicking activity; current animal studies indicate that SLU-PP-332 raw material is associated with increased energy expenditure in obese mice.
| Name | SLU-PP-332 |
| IUPAC Name | 4-hydroxy-N-[(E)-naphthalen-2-ylmethylideneamino]benzamide |
| CAS NO | 303760-60-3 |
| InChI | InChI=1S/C18H14N2O2/c21-17-9-7-15(8-10-17)18(22)20-19-12-13-5-6-14-3-1-2-4-16(14)11-13/h1-12,21H,(H,20,22)/b19-12+ |
| Regulatory Status | Not approved by the FDA |
| Response | Gene-expression dependent |
| Key co-regulator | PGC-1α/PGC-1β |
| Application | Mitochondrial & oxidative metabolism/skeletal muscle metabolism |
SLU-PP-915: A Newer Orally Bioavailable Pan-ERR Research Compound
SLU-PP-915 CAS 2285432-92-8
SLU-PP-915, a pan-ERR agonist (ERRα / ERRβ / ERRγ), is similar to SLU-PP-332 but is a version with improved oral bioavailability. Its applications include metabolic research areas such as obesity and type 2 diabetes.
| Name | SLU-PP-915 |
| IUPAC Name | [3-[5-[(2-fluorophenyl)carbamoyl]thiophen-2-yl]phenyl]boronic acid |
| CAS NO | 2285432-92-8 |
| InChI | InChI=1S/C17H13BFNO3S/c19-13-6-1-2-7-14(13)20-17(21)16-9-8-15(24-16)11-4-3-5-12(10-11)18(22)23/h1-10,22-23H,(H,20,21) |
| Regulatory Status | Not approved by the FDA |
| Similar Products | SLU-PP-332, O-304/ATX-304, 5-amino-1-mq |
ATX-304 vs SLU-PP-332 vs SLU-PP-915
| Compound | CAS | Primary Target | Research Direction |
|---|---|---|---|
| ATX-304 | 1261289-04-6 | AMPK | Cellular energy signaling |
| SLU-PP-332 | 303760-60-3 | ERRα/β/γ | Mitochondrial metabolism |
| SLU-PP-915 | 2285432-92-8 | ERRα/β/γ | ERR-mediated metabolic research |
View More:
SLU-PP-915 VS SLU-PP-332: What are the differences between these pan-err agonists?
ATX-304 vs SLU-PP-332: Mechanisms, Research Applications and Key Differences
How to Choose Between an AMPK Activator and an ERR Agonist?
Choose an AMPK-Targeting Compound
If your research focuses on studying cellular energy sensing, investigating AMPK signaling, examining phosphorylation-related metabolic responses, comparing energy-stress pathways, and more, AMPK activators such as atx-304 are excellent choices
Choose an ERR-Targeting Compound
If your research focuses on studying mitochondrial transcription, researching oxidative metabolism, investigating ERR/PGC-1α signaling, or studying mitochondrial gene expression, SLU-PP-332 and SLU-PP-915 are better choices.
What Should B2B Buyers Check When Sourcing These Research Compounds?
Confirm CAS Numbers
When sourcing, procurement personnel must confirm the CAS numbers for the following small-molecule compounds:
ATX-304: CAS 1261289-04-6
SLU-PP-332: CAS 303760-60-3
SLU-PP-915: CAS 2285432-92-8
Confirming Purity
Whether purchasing in bulk or ordering samples, it is necessary to confirm HPLC purity-such as the COA data for SLU-PP-915-and verify batch consistency and analytical data.
FAQ
1. What is the difference between ERRα and AMPK?
The primary function of AMPK is to sense the cell's energy status; its representative compound is o-304 powder. The primary function of ERRα is to regulate the transcription of metabolism-related genes and modulate the expression of genes associated with mitochondrial and oxidative metabolism; its representative compounds are SLU-PP-915 and SLU-PP-332.
2. Is ERRα part of the AMPK pathway?
Yes, ERRα and AMPK are not two independent systems; they are closely related and are integral components of mitochondrial biosynthesis and metabolism.
3. What is ATX-304?
o-304 (also known as ATX-304) is a powder widely used in various fields of chemical research. It is a synthetic compound. ATX-304 manufacturer-Jinan Jianfeng Chemical supplies high-purity ATX-304 raw material powder, suitable for various types of experimental research.
4. What is SLU-PP-332?
SLU-PP-915, a compound that can induce DNA damage-induced transcript 4, is a synthetic small-molecule pan-ERR agonist.
5. What is SLU-PP-915?
The oral bioavailability of SLU-PP-915 has been improved compared to that of SLU-99-332; these are potential ERR agonists that have been shown to target all three isoforms of the ERR (ERRα, ERRβ, and ERRγ).
Disclaimer:
The information on this website is for communication and learning purposes only and is not medical advice. It should not be used for diagnosing or treating any illness.
References
PubMed Central. PMC10801787. National Library of Medicine.
National Library of Medicine. PubMed PMID: 36089981. PubMed.
PubMed Central. PMC12814917. National Library of Medicine.
PubMed Central. PMC8302669. National Library of Medicine.
Richter EA, Ruderman NB. AMPK and the biochemistry of exercise: Implications for human health and disease. Biochemical Journal. 2009;418(2):261–275. doi:10.1042/BJ20082055.
