Capecitabine Powder

Pharmaceutical Raw Material CAS 154361-50-9 99% Purity Capecitabine

What Is Capecitabine Powder?

Capecitabine serves as a primary treatment option for patients diagnosed with colorectal cancer. Additionally, it is administered either alone or in conjunction with docetaxel to individuals with metastatic breast cancer who have undergone anthracycline therapy but have experienced disease advancement or recurrence.

Besides causing bone marrow suppression, nausea, and vomiting, this medication can also lead to severe diarrhea and a potentially debilitating condition known as "hand-and-foot syndrome" (palmar-plantar erythrodysesthesia). By inhibiting CYP2C9 and competing for serum protein binding sites, capecitabine can produce clinically relevant drug interactions with both warfarin and phenytoin.

Capecitabine (capecitabine) is an antimetabolizing fluoropyrimidine deoxyriboside carbamate that can be converted to 5-FU in vivo by a synthetic route:

Starting with D-ribose, after methylation of the 1-hydroxy group and protection of the 2,3-hydroxy groups, 2,3-O-isopropylidene-D-furanosyl methyl glycoside is obtained.

Reacting with p-toluenesulfonyl chloride in the presence of pyridine yields 2,3-O-isopropylidene-5-O-p-toluenesulfonyl-D-furanosyl methyl glycoside.

Subsequent iodination with sodium iodide gives 2,3-O-isopropylidene-5-iodo-D-furanosyl methyl glycoside.

Reduction with Pd/C catalytic hydrogenation results in 2,3-O-isopropylidene-5-deoxy-D-furanosyl methyl glycoside.

Deprotection with sulfuric acid and acetylation with acetic anhydride yield 1,2,3-tri-O-acetyl-5-deoxy-D-ribose.

Condensation with 5-fluorouracil in the presence of anhydrous tin tetrachloride produces 2',3'-di-O-acetyl-5'-deoxy-5-fluorocytidine.

Reaction of 2',3'-di-O-acetyl-5'-deoxy-5-fluorocytidine with pentyl chloroformate gives 2',3'-di-O-acetyl-5'-deoxy-5-fluoro-N4-[(pentyloxy)carbonyl]cytidine.

Finally, hydrolysis with sodium hydroxide yields the final product, Capecitabine.

who choose us?

 

1.More than 10 years chemical exporting experience

We have produced chemical more than fifteen years., 80% products are for export .

More than 10 years chemical exporting experience. Good and stabilized factory price.

2.Strict quality control system

We has passed through the ISO9001:2015 Quality System Certificate, we have strict quality control system

3.Supply sample

Before order , we can send the sample for your testing . We ensure the quality is the same as bulk quantity .

one-stop solution

professional team

high quality

How To Cooperate With Us?

--Contact us via Email.

 

--Leave us a message about the products you want.

 

--Description of order quantity.

 

--Please tell us your shipping address.

 

--The sales manager gives you a quote and sends you a contract.

 

--Delivery the same day after payment.

Hot Tags: capecitabine powder, China, suppliers, manufacturers, factory, wholesale, buy, bulk, price, for sale, in stock, Purity 99 Ibrutinib Powder, Inhibitor LOXO 292, Pharmaceutical Peptide, 99 Purity Tieneptin Free Acid, Tianeptine Free Acid Powder, Flumazenil Powder