NMN Can Improve Hypothalamus (central Nervous System) Function Decline Caused By Aging
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On January 25, 2023, the research team of Kobe Institute of Biomedical Research, Tokyo Institute of Aging, and Washington University School of Medicine published a research report on the international research journal "NPJ Aging" [1], proving that aging animals can restore the arch of the hypothalamus by taking NMN Nuclei (neurons clustered at the base of the hypothalamus), intraventral hypothalamus (obesity and gonadal atrophy are caused by damage), and external hypothalamus (responsible for appetite control and satiety regulation) NAD+ further proves that taking NMN is a Effective anti-aging method.
1. The hypothalamus is the advanced control center of aging
The hypothalamus has been shown to be a high-level control center of aging in mammals, playing a key role in regulating mammalian aging and longevity. In these two Asian regions, the NAD+-dependent protein deacetylase Sirt1 cooperates with the homeodomain transcription factor Nkx2-1 to regulate the expression of key genes, promote neuronal activity, delay aging, and prolong lifespan in mice.
NAD+Sirt1 activity declines with age. NAD+ supplement NMN can effectively improve and help delay aging.
2. NMN, aging leads to hypothalamus function decline
The study compared the local NAD+ changes in the hypothalamic nuclei of 3-month-old mice (equivalent to 20 years in humans) and 22-month-old mice (equivalent to 60 years in humans), and found that the hypothalamic arcuate nucleus (ARC), NAD+ levels in the ventromedial hypothalamus (VMH) and outer hypothalamus (LH) were significantly reduced in 22-month-old mice.
After the researchers gave 300 mg/kg NMN to aged mice, they found that the arcuate nucleus of the hypothalamus (ARC, neurons gathered in the base of the thalamus), the ventral hypothalamus (VMH, damage to the outer hypothalamus leads to obesity and gonadal atrophy) ( LH, controls appetite, regulates satiety) and the dorsal core of the hypothalamus (DMH, NAD+ levels are significantly increased, and stress elicits cardiovascular responses).
The results showed that DNA damage and inflammation lead to a decline in thalamic function with age, and that decreased NAD+ levels lead to insomnia, significant declines in physical activity, and cognitive performance. Taking NMN to supplement NAD+ can restore and maintain youthful NAD+ levels, significantly delay aging symptoms, and thus improve sleep, activity and cognitive ability.
