ACT-132577 Powder

ACT-132577 is a member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist, a drug metabolite and a xenobiotic metabolite. It is an aromatic ether, an organobromine compound, a member of pyrimidines and a member of sulfamides. It is functionally related to an ethylene glycol.

The principle by which ACT-132577 (Aprocitentan)Powder reduces blood pressure can be simply understood as follows: It blocks endothelin, a hormone involved in regulating the movement of blood vessels, which causes blood vessels to contract. ACT-132577 (Aprocitentan) Powder promotes vasodilation, or relaxation of blood vessels, by blocking this hormone.

However, this drug also has certain side effects, the most common side effects in trials are edema, fluid retention and anemia, and it can cause birth defects, so people who may become pregnant must take a negative pregnancy test before starting Aprocitentan treatment, and should use contraception and monthly pregnancy tests while taking the drug. If pregnant, the drug must be stopped immediately.

Currently, ACT-132577 (Aprocitentan) Powder is primarily used in patients who have taken the highest available dose of blood pressure medication but still have poorly controlled blood pressure.

Finally, still want to remind you, here is only to share information, we must not take drugs without authorization.

BEST BUSINESS PARTNER- Jinan Jianfeng Chemical

Jianfeng Chemical is a research-driven pharmaceutical company.We have more than 10 years experience in the pharmacy filed. Mainly manufactures pharmaceutical APIs,Pharmaceutical intermediate and Cosmetic raw material. Owing to the good quality and competitive price, we have a very good reputation in China's pharmaceutical circles.

In the principle of "Quality Oriented", Jianfeng passed the certification of ISO9001:2008 Quality Management System.

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