Dabigatran Etexilate Mesylate

CAS number: 872728-81-9

Molecular formula: C35H45N7O8S

Molecular weight: 723.85

EINECS Number: 828-727-6

Dabigatranetexilatemesylate(BIBR1048MS;oral;10,20and50mg/kgforratsand1,2.5and5mg/kgformonkeys)hasdose-andtime-dependentanticoagulanteffectsandhasmaximumeffectsbetween30and120minafteradministration,respectively.Dabigatranetexilatemesylatemaximallyandsignificantlyprolongspartialthromboplastintime(aPTT)to25.2,38.4and78.3sin30minafter10,20and50mChemicalbookg/kgoraldoses,respectively.DabigatranetexilatemesylatemaximallyprolongstheaPTTto34.3s,44.0s,and63.0s,respectively,2hafter1,2.5or5mg/kgdosesinthemonkey.AnimalModel:Malerats(280-350g)andrhesusmonkeysofeithersex(3-8kg)Dosage:10,20and50mg/kgforratsand1,2.5and5mg/kgformonkeysAdministration:OralResult:Haddose-andtime-dependentanticoagulanteffects.

Melting point: >125°C
Storage Conditions: Refrigerator
Solubility: DMSO (Slightly, Heated), Methanol (Slightly)
Form: Solid
Color: White to Pale Yellow

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