What is AF710B? A Guide to Its Properties and Applications

What is AF710B?

AF710B (also known as ANAVEX 3-71) is a small molecule chemical compound that mainly acts on M1 muscarinic receptors and sigma-1 receptors. As a selective allosteric agonist, AF710B may participate in related biological signaling processes by regulating specific receptor activities.

The M1 muscarinic receptor is a part of the cholinergic system and is associated with neuronal signaling processes. The sigma-1 receptor is an intracellular receptor related to cellular communication, neuronal function regulation, and cellular stress-related processes. By acting on these two types of receptors simultaneously, AF710B can be used to explore cognitive-related processes, synaptic function, and molecular pathways involved in nervous system regulation.

Key Properties of AF710B

One of the key characteristics of AF710B is its dual receptor activity. Unlike compounds that target only one receptor type, AF710B can act on both M1 muscarinic receptors and sigma-1 receptors, allowing it to be used for studying interactions between different signaling pathways.

AF710B is an allosteric modulator compound, and its mechanism differs from compounds that directly bind to the active site of receptors. Allosteric modulation refers to the process in which a compound binds to a different site on a receptor, thereby influencing receptor conformation and activity status.

In addition, AF710B has a defined small molecule chemical structure and can serve as a reference compound in receptor-related studies to explore receptor functions, molecular interactions, and related biochemical processes.

Product Name: AF710B Powder
CAS: 1235733-73-9
MF: C20H27N3OS
MW: 357.51
Shelf Life: 2 years

 

What Makes AF710B Different?

The difference between AF710B and many traditional neuroactive compounds is that it involves two activity pathways: M1 muscarinic receptors and sigma-1 receptors.

M1 receptor activation is associated with cholinergic signaling, while sigma-1 receptors are involved in various intracellular regulatory processes, including calcium balance, cellular stress responses, and synaptic-related functions. Due to its activity on two different receptor systems, AF710B can be used to study connections between different signaling pathways. This dual-target characteristic distinguishes it from compounds mainly designed to act on a single biological pathway.

Currently, AF710B has also been used in studies related to cognitive function and nervous system changes. For example, related studies have explored its effects on synaptic markers, amyloid-related pathways, and cognitive performance. However, its specific biological effects still require further research and validation.

 

Potential Applications of AF710B Powder

AF710B powder can be applied in multiple research areas related to molecular biology and neuroscience.

1. Neuroscience Research

AF710B can be used as a research compound to explore M1 muscarinic receptors, sigma-1 receptors, and related neuronal signaling pathways. It may help study receptor activity, synaptic communication, and neuronal regulation processes.

2. Nootropics-Related Research

Due to its interaction with receptors related to brain signaling, AF710B may be used in research on compounds associated with cognitive functions. It can serve as a reference compound for exploring molecular mechanisms related to memory, learning, and neuronal functions.

3. Chemical and Pharmaceutical Research

As a small molecule chemical compound, AF710B can be used in compound screening, molecular interaction studies, and research involving receptor-targeted compounds.

 

In addition to Af710b, we also produce other high-quality pharmaceutical APIs.

If you have any inquiries or requirements, please feel free to contact us at: sales01@pharmachemm.com

 

References and Supporting Sources

[1] Fisher A, Bezprozvanny I, Wu L, Ryskamp DA, Bar-Ner N, Natan N, Brandeis R, Elkon H, Nahum V, Gershonov E, LaFerla FM, Medeiros R. (2016). AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer's Disease. Neurodegener Dis.

[2] Hélène Hall, Maria Florencia Iulita, Palma Gubert, Lisi Flores Aguilar, Adriana Ducatenzeiler, Abraham Fisher, Augusto Claudio Cuello. (2018). AF710B, an M1/sigma-1 receptor agonist with long-lasting disease-modifying properties in a transgenic rat model of Alzheimer's disease. Alzheimer's & Dementia

Disclaimer:

The information on this website is for communication and learning purposes only and is not medical advice. It should not be used for diagnosing or treating any illness.