Paclitaxel Powder

What is Paclitaxel Powder?

Paclitaxel is a well-known chemotherapy drug used in the treatment of various cancer types, including ovarian, breast, and lung cancers. It is a natural product of the Pacific yew tree, Taxus brevifolia, extracted from its bark and needles. However, the drug cannot be directly obtained from natural sources since the Pacific yew tree is slow-growing and has limited availability.

Therefore, paclitaxel is synthesized through a semi-synthetic process in the laboratory. This process involves the isolation of the compound 10-DAB (10-deacetylbaccatin III) from the needles and branches of the yew tree, which is then chemically modified to produce paclitaxel. However, this process is complicated and expensive, making it a challenging drug to manufacture in bulk.

Paclitaxel Powder Properties

Paclitaxel powder is a white to off-white crystalline powder that is insoluble in water. It is typically packaged in sterile, single-use vials, and is administered intravenously. The chemical name of paclitaxel is 5β,20-Epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine.

Mechanism of Action

Paclitaxel works by binding to and stabilizing microtubules, which are essential components of the cytoskeleton of cells. Microtubules are involved in cell division and crucial for the formation of the mitotic spindle, which separates chromosomes during cell division. Paclitaxel disrupts this process, leading to the arrest of cell division and the death of cancer cells.

Uses of Paclitaxel Powder

Paclitaxel is used in the treatment of various cancer types. It is approved in the United States for the treatment of breast, ovarian, and non-small cell lung cancer. It is also used off-label for the treatment of other types of cancer, such as prostate, bladder, and pancreatic cancer.

Side Effects

Like all medications, paclitaxel has side effects. Some common side effects of paclitaxel include hair loss, nausea, vomiting, and fatigue. Other side effects may include low white blood cell count, anemia, peripheral neuropathy, muscle and joint pain, and allergic reactions. Patients receiving paclitaxel should be closely monitored for these side effects.

Packing & Shipping

BEST BUSINESS PARTNER- Jinan Jianfeng Chemical

Jinan Jianfeng Chemical passed the certification of ISO9001:2008 Quality Management System. Headquartered in Jinan, China, which is specialized in the development, production and sales of pharmaceutical intermediates, APIs (active pharmaceutical ingredients), cosmetic raw materials and fine chemicals.

Our Products are mainly sold to North America, Europe, South America, Australia and the Middle East and other countries.

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