Terbinafine HCL API Powder

 

Terbinafine hcl powder cas 78628-80-5 is used to treat certain types of fungal infections (for example, of the fingernail or toenail). It works by stopping the growth of fungus. This medication belongs to a class of drugs known as antifungals.

 

Product Name	Terbinafine HCl
CAS	78628-80-5
Appearance	White to off-white powder
Molecular formula	C21H26ClN
Molecular Weight	327.89
EINECS	616-640-4
Assay	99%
Solubility	Very slightly or slightly soluble in water, freely soluble in anhydrous ethanol and in methano.l, slightly soluble in aceton.e.
Shelf Life	2 Years

 

Terbinafine HCl may exhibit antifungal activity by interfering with fungal cell membrane formation. Its potential mechanism mainly involves the following processes:

1. Inhibition of ergosterol synthesis
Terbinafine HCl may selectively inhibit fungal squalene epoxidase, an enzyme involved in the early stage of ergosterol biosynthesis. By reducing ergosterol production, it may affect the normal structure and function of fungal cell membranes.

2. Disruption of fungal cell membrane integrity
The inhibition of ergosterol synthesis may lead to the accumulation of squalene within fungal cells and may cause changes in membrane stability. These effects may contribute to impaired fungal cell growth and may support the antifungal activity of Terbinafine HCl.

 

 

Terbinafine HCl is mainly used as an active pharmaceutical ingredient (API) in antifungal formulations. It may be applied in the development of various pharmaceutical products designed for the management of fungal infections, including:

Topical antifungal formulations: Terbinafine HCl may be used in creams, gels, sprays, and other topical preparations intended for localized skin fungal conditions.

Dermatological applications: It may be incorporated into formulations for research and development related to fungal infections affecting the skin, nails, and other keratinized tissues.

Pharmaceutical formulation development: Terbinafine HCl may serve as an active ingredient for developing and optimizing antifungal drug formulations, including stability studies and dosage form research.

 

 

Item Of Analysis	Standard	Result Of Analysis
Description	White or almost white powder	almost white powder
Solubility	Very slightly or slightly soluble in water, freely soluble in anhydrous ethanol and in methanol, slightly soluble in acetone	Complies
Identification	Infrared absorption spectrophotometry. Comparison: terbinafine hydrochloride CRS	Complies
	It gives reaction (a) of chlorides using anhydrous ethanol R as solvent	Complies
Related Substances	Impurity B: not more than 0.15%,	Complies
	Impurity E: not more than 0.05%, impurity	Complies
	unspecified impurities:each Impuritynot more than 0.1%	Complies
	Sum of impurity : not more than 0.3%	Complies
Loss on drying	≤0.5%	0.40%
Sulfated ash	≤0.1%	0.01%
Residual Solvent	ethyl acetate≤0.5%	ethyl acetate≤0.5%
	dichloromethane≤0.06%	dichloromethane≤0.06%
	isopropanol≤0.5%	isopropanol≤0.5%
Assay	99.0%-101.0%	100.29%

 

 

Packing:

1. Weight <1kg ---- Fluorinated bottle

2. 25kg ---- Plastic bucket

3. 180- 200kg ---- Drum

P.S.: we accept packaging customization.

Shipping:

We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg.

Shipping details & shipping documents will be provided and sent to customers as long as it is ready.

We keep tracking the shipment until clients well received.

After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safely and efficiently.

Delivery:

We have large quantity raw powder in stock, normally could ship out within 3 working days.

For rush delivery, please contact our sales team for particular arrangement.

 

 

 

How does Terbinafine HCl work?
Terbinafine HCl may exert antifungal activity by inhibiting fungal squalene epoxidase, an enzyme involved in ergosterol biosynthesis. This may interfere with fungal cell membrane formation and help affect fungal cell growth.

 

What is the difference between Terbinafine and Terbinafine HCl?
Terbinafine HCl is the hydrochloride salt form of Terbinafine. The salt form may offer improved stability and formulation properties compared with the free base form, making it commonly selected for pharmaceutical applications.

 

Are you a manufacturer of Terbinafine HCl powder (CAS 78628-80-5)?

A: Yes, we are a professional manufacturer and supplier of Terbinafine HCl powder. We provide high-quality raw materials with strict quality control, batch consistency, and supporting documents such as COA and testing reports. Bulk supply and customized packaging services are available for global customers.

 

Which kind of payment terms doyou accept?

For small order,you can pay byT/T, trade assurance or Paypal, commercial order by T/T to our company account.

 

When will the product be shipped after payment?

The parcel will be get ready and shipped within 1days.

 

Can l get some samples?

Yes, we can supply the fre sample, but the shiping cost be paid by cusomers.

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