Pure Peramivir

CAS No.: 229614-55-5

Molecular formula: C15H28N4O4

Molecular weight: 328.41

EINECS No.: 1308068-626-2

new anti-flu drug

Influenza (abbreviated as "flu") is a respiratory infectious disease caused by influenza virus infection. The viruses that cause influenza are generally divided into three types, namely type A (A), type B (B) and type C (C). The type A is easy to break out, spread and spread in the crowd. The main drugs are oseltamivir, zanamivir and peramivir, which has just been approved for marketing. The targets of these drugs are mainly the neuraminidase of the virus. Peramivir was first developed by BioCryst in the United States, and was first approved for marketing in Japan in January 2010 after the introduction of Shionogi Pharmaceutical in Japan. The drug can be used in patients with severe disease, resistance to Tamiflu and patients who cannot take it orally. On April 5, 2013, the State Food and Drug Administration approved the new anti-influenza drug Peramivir Sodium Chloride Injection. According to the website of the State Food and Drug Administration, peramivir is a new type of anti-influenza drug, and the existing clinical trial data proves that it is effective against influenza A and influenza B. H7N9 belongs to the influenza A virus subtype. Peramivir Sodium Chloride Injection is the first neuraminidase inhibitor administered intravenously in my country. Patients with poor response to or resistance to inhibitors provide new treatment options. According to the State Food and Drug Administration, the National Drug Evaluation Department conducted a strict review of Peramivir Sodium Chloride Injection in accordance with the regulations for new drug evaluation. Chemicalbook adopted support measures such as early intervention in research and development, strengthening communication and guidance, and On the premise of ensuring the safety and effectiveness of drugs, speed up the approval process to meet clinical needs. At present, as neuraminidase inhibitor drugs, oseltamivir phosphate tablets and zanamivir inhalation are also approved for marketing in my country. my country is one of the few countries that have approved the listing of peramivir such as the United States, Japan, and South Korea. The State Food and Drug Administration did not specifically disclose the pharmaceutical companies that have been approved for production this time. Guangzhou Nanxin Pharmaceutical Co., Ltd. is currently the only domestic company that produces Peramivir Sodium Chloride Injection.

Advantages over oseltamivir

Peramivir and oseltamivir (trade name "Tamiflu") both belong to neuraminidase inhibitors, and their antiviral mechanism is the same as that of oseltamivir, so they are suitable for the treatment of influenza A. The clinical trials carried out by peramivir used oseltamivir as the control drug, and the test results showed that there was no significant difference between its curative effect and adverse reactions compared with oseltamivir. Oseltamivir is an oral preparation, which is not convenient for severe patients to use, and due to its relatively early marketing time, it has been found that drug resistance has emerged. Peramivir has a different structure from oseltamivir, and is suitable for the treatment of patients resistant to oseltamivir; in addition, because peramivir is an injection with a long half-life, it also has the advantages of rapid onset and long duration in clinical use. specialty. The approval of peramivir provides a new treatment option for patients with severe influenza, patients who cannot receive inhalation or oral drug treatment, and patients who are resistant to oseltamivir.

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