Dabigatran Mesylate
CAS:872728-81-9
MF:C35H45N7O8S
MW:723.85
EINECS:828-727-6
form:Solid
MOQ:1KG
Description
What is Dabigatran mesylate?
Dabigatran mesylate is a drug which is frequently used to treat a variety of cardiovascular diseases, particularly stroke, atrial fibrillation, and deep vein thrombosis.This medication works by inhibiting the activity of thrombin, a protein involved in the clotting of blood.
Dabigatran mesylate uses:
For patients experiencing atrial fibrillation, dabigatran mesylate is an effective alternative to the standard anticoagulant warfarin. Warfarin requires frequent monitoring and dosage adjustments, while dabigatran mesylate can be administered in a fixed dose without the need for monitoring. Additionally, dabigatran mesylate does not carry the same risk of bleeding as warfarin, especially in elderly patients.
Dabigatran mesylate is also used for the prevention of deep vein thrombosis and pulmonary embolism in patients who have undergone major orthopedic surgery. Patients who receive this medication are less likely to experience blood clots and other thrombotic events.
Dabigatran mesylate synthesis:
The synthesis of dabigatran mesylate involves several steps. Initially, the molecule is constructed using linear and convergent strategies. The final step of the synthesis involves the conversion of dabigatran etexilate into the mesylate form through reaction with methanesulfonic acid.
Dabigatran mesylate benefits:
One of the major benefits of dabigatran mesylate is its oral bioavailability. The drug is rapidly absorbed after oral administration, and has a half-life of approximately 12-14 hours in healthy patients. This makes it an attractive option for long-term anticoagulation therapy.
In summary, dabigatran mesylate is a widely used medication for the treatment and prevention of cardiovascular diseases. Its efficient oral bioavailability, lack of need for monitoring, and lower bleeding risk makes it a practical alternative to other anticoagulants.
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