Erlotinib
Erlotinib Application: Anti-tumor drugs It is used for the second-line treatment of locally advanced or metastatic non-small cell lung cancer. It has recently been approved by the US FDA for combination with gemcitabine as a first-line treatment for advanced pancreatic cancer.
Description
Erlotinib
synonyms:4-[(3-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline; n-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine; 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-; ERLOTININ; Erlotinib & its intermediates; Erlotinib Base
1.CAS No.: 183321-74-6
2.Molecular formula: C22H23N3O4
3.Molecular weight: 393.44
4.InChI: InChI=1/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)
5.Properties: white crystalline powder
6.Content: 99%
7.Use: anti-tumor drug
Erlotinib is a tyrosine kinase inhibitor (TKI) which is a type of cancer growth blocker. It blocks proteins on cancer cells that encourage the cancer to grow.
Erlotinib Dosage and Usage Non-small cell lung cancer: 150mg/d; administrate at least1h before meals or 2h after meal; continue taking the drug until the disease get progression or the emergence of intolerable toxicity response when the patients should withdraw the drug.
Pancreatic cancer: combine with gemcitabine for 100mg /d at least 1h before meals or 2h after meals; continue taking the drug until the disease get progression or the emergence of intolerable toxicity response when the patients should withdraw the drug.
Upon severe liver insufficiency, the drug dosage should be reduced or temporarily discontinued, elderly patients do not have to adjust the dose.
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