Apremilast API Powder

Apremilast API powder

Melting point 152-156 ° C
Boiling point 741.3 ± 60.0 ° C (Predicted)
Density 1.381
Storage conditions: Refrigerator
Solubility: soluble in chloroform (mild), DMSO (mild), methanol (mild, heated), acidity coefficient (pKa) 14.01 ± 0.20 (Predicted), solid color: white to light yellow, InChIKeyIMOZEMNVLZJZ-QGZVFWFLSA-NSMILESC (NC1=CC=CC2=C1C (=O) N ([C @ @ H] (C1=CC=C (OC) C (OCC)=C1), CS (C) (=O)=O), C2=O) (=O)
CAS database 608141-41-9

Drug Overview Name: Apremilast Alias: N/A, CC-10004 English Name: apremilast Product Name: Otezla Chinese Name: S) -2- [1- (3-ethoxy-4-methoxyphenyl) -2-methylsulfonylethyl] -4-acetylaminoisoindoline-1,3-dione English Chemical Name: (+)-N-［2-［1(S)-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyChemicalbookl］-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl］acetamide Molecular formula: C22H24N2O7S Molecular weight: 460.5 CAS number: 608141-41 Original research company: Celgene Pharmacological classification: dual inhibitors of phosphodiesterase-4 (PDE-4) and tumor necrosis factor - α (TNF - α) Indications: psoriasis, psoriatic arthritis Current stage: Phase III Clinical administration route: oral

Apremilast, a psoriasis treatment drug, is an oral, selective phosphodiesterase 4 (PDE4) inhibitor developed by Celgene Corporation in the United States. Its trade name is Otezla, and it is the first and only PDE4 inhibitor approved by the FDA for the treatment of plaque psoriasis. It is used for the treatment of moderate to severe plaque psoriasis in adult patients suitable for phototherapy and systemic therapy. On March 21, 2014, the US FDA approved Otezla (apremilast) for the treatment of adult patients with active psoriatic arthritis (PsA). Most people first develop psoriasis and then are diagnosed with PsA. Joint pain, stiffness, and swelling are the main signs and symptoms of PsA. The drugs currently approved for PsA include glucocorticoids, tumor necrosis factor (TNF) blockers, and interleukin-12/interleukin-23 inhibitors. Otezla is a phosphodiesterase-4 (PDE-4) inhibitor, and its safety and efficacy are based on three phase 3 clinical trials involving 1493 active psoriatic arthritis patients. Compared with placebo patients, patients treated with Otezla showed improvement in PsA signs and symptoms. The ACR20 response rates in the apremilast group and placebo group were 32-41% and 18-19%, respectively. Aplast is a novel oral anti rheumatic drug with a different mechanism of action from commonly used anti TNF monoclonal antibodies in clinical practice. EvaluatePharma predicts sales of $1.219 billion in 2018. Otezla treatment patients should have their weight monitored regularly by healthcare professionals. If unexplained or clinically significant weight loss occurs, weight loss should be evaluated and treatment should be considered for discontinuation. Compared with placebo patients, patients treated with Otezla have an increased risk of depression. In clinical trials, the most common side effects of Otezla medication in patients are diarrhea, nausea, and headache. Otezla is produced by Searle Genomics, located in Summit, New Jersey

If there is a product quality problem, if the test is unqualified, there is after-sales guarantee, we can return and exchange the product free of charge, so that you have no worries.

FAQ

Q1: When will the product be shipped after payment?
---We are committed to the same day shipping.

Q2. How does your factory control quality?
All the raw material purchasing and production quality control are strictly following the ISO9001: 2008 management system. Besides, the full-featured detection equipment and GMP quality management system provided the strongest guarantee for a high-quality product.


Q3: How long will it take to receive the parcel?
--3 days for the US market; 4-6 days for the others.

Q4: What can I do if I don't have the ability to clear the custom?
--We got experience after doing export for many years, so don't worry we can handle that.

Q5: Can I get some samples?
---Yes.

Q5: What about after-sale service?
---We promise to reissue free of charge if there is any problem.

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