What is Delafloxacin?

Chemical Classification

Fluoroquinolone antibiotic (4th generation modified), chemical name: Delafloxacin.

Structural features: Amphoteric ionic structure (coexistence of acidic/basic groups), enhanced tissue penetration and target binding.

R&D Background

Developed in response to the escalation of resistance to traditional quinolones, it enhances the therapeutic efficacy against gram-positive bacteria (e.g. MRSA) and complex infections.

Core Functions and Mechanisms of Action
Antimicrobial Spectrum Properties

Broad spectrum coverage:

Gram-positive bacteria: Staphylococcus aureus (including MRSA), Streptococcus pneumoniae.

Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Haemophilus influenzae.

Atypical pathogens: Mycoplasma pneumoniae, Chlamydia.

Anti-drug resistance advantage: maintain high susceptibility to multi-drug resistant bacteria (e.g. methicillin-resistant strains).

Mechanism of action

Dual target inhibition:

Inhibits bacterial DNA rotamase (topoisomerase II) and topoisomerase IV, blocking DNA replication and repair.

Stronger target binding to resistant bacteria than other quinolones.

Pharmacodynamic (PD) characteristics

Concentration-dependent bactericidal activity, high dose short course strategy recommended to maximise efficacy and reduce risk of resistance.

Jinan Jianfeng Chemical Co.,ltd supply Delafloxacin raw material powder, can be used for experimental research, the company has more than 10 years of experience in the production of API, intermediates export, each batch of goods before leaving the factory have a strict inspection process, not recommended for personal purchase, if your company needs Delafloxacin powder, please contact us!