What are the apixaban intermediates?

Dec 08, 2025

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Apixaban is an anticoagulant that inhibits thrombin generation and is clinically used to prevent venous thromboembolism in patients undergoing knee surgery.

Apixaban

The following are the types of intermediates used in the synthesis of apixaban API.

Apixaban intermediate
Product Name	CAS	Structure
1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester	503614-91-3
Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate	27143-07-3
3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one	536760-29-9
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one	545445-44-1
3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one	503615-03-0
ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate	536759-91-8
ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate	503615-07-4
1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone	1267610-26-3
Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate	473927-63-8

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