Home - Products - Pharmaceutical API - Details

Prilocaine Powder

Name: China Prilocaine Powder Suppliers, Manufacturers - Factory Direct Price - Jianfeng Chemical
Brand: Jianfeng
SKU: 211737314

CAS:721-50-6
MF:C13H20N2O
MW:220.31
EINECS:211-957-0
MOQ:1KG
Delivery: 3-5days
Melting point:37-38°

Send Inquiry

Description

CAS:721-50-6
MF:C13H20N2O
MW:220.31
EINECS:211-957-0
MOQ:1KG
Delivery: 3-5days
Melting point:37-38°

astra1512;o-Propionotoluidide,2-(propylamino)-(6CI,8CI);Propanamide,N-(2-methylphenyl)-2-(propylamino)-(9CI);N-(2-methylphenyl)-2-(propylamino)Chemicalbookpropionamide;Prilocaine(200mg);2-(PropylaMino)-N-(o-tolyl)propanaMide;PrilocaineHCl(base);PrilocaineN-(2-Methylphenyl)-2-propylamino-propanamide

CAS No.: 721-50-6

Molecular formula: C13H20N2O

Molecular weight: 220.31

EINECS number: 211-957-0

Mr. Ted

-Sales manager

 Tel: +8615628852771

 Whatsapp: 8615628852771

 Wechat: 8615628852771

FAX: 0086-531-88113608

Email: sales09@pharmachemm.com

Web:www.jianfengchemical.com www.pharmachemm.com

Add: 311-2, R&D Building 1, No. 554 Zhengfeng road, High-

Tech zone,Jinan City, Shandong, China.

product-730-730

local anesthetic

Prilocaine is an amide local anesthetic. The anesthesia strength and speed are similar to lidocaine, but the duration is longer and the vasodilation effect is weaker. Toxicity is lower than lidocaine. It is clinically used for local anesthesia, especially for patients who are forbidden to use epinephrine.

[Pharmacology] The local anesthetic effect of its 3% solution is equivalent to that of 2% lidocaine plus epinephrine, the onset of effect is slow, about 6-7 minutes, the maintenance time is about 1.5-2 hours, and it has strong penetration into the mucous membrane. Epinephrine prolongs its action slightly. PPB is 55%, T1/2 is about 1.5h. Metabolized in the liver, its metabolite nitrosotoluidine can oxidize hemoglobin to form methemoglobin. Can be transferred to the fetus through the placenta.

[Adverse reactions] If the dosage exceeds 600mg at one time, methaemoglobinemia, cyanosis, tachycardia, headache, dizziness and weakness may occur.

[Precautions] It is forbidden for patients with anemia, congenital or acquired methaemoglobinemia, heart failure and respiratory failure or hypoxia. Avoid for obstetric anesthesia.

[Usage and Dosage] Infiltration anesthesia: use 0.5% to 1% solution, and the duration of action is 1 to 1.5 hours. Nerve block anesthesia: use 1% to 2% solution, and the duration of action is 2 to 3 hours. Epidural anesthesia: use 10-30ml of 1%-1.5% solution, and the duration of action is 2.5-3.5 hours. A maximum dose of 600mg. Figure 1 is the structural formula of prilocaine. The above information is edited by Chemicalbook Dongfang of Chemicalbook.

biological activity

Prilocaine (NSC40027) is an aminoamide local anesthetic. It acts on sodium ion channels in neuronal cell membranes, limiting the spread of seizures.

target

Na,K-ATPase

in vitro studies

Prilocaine is more potentin inhibiting the Na, K-ATPase of plasma membranes of LM cells (transformed fibroblasts) at37℃(43.8mM) than at25℃(28.2mM).

chemical properties

Needle crystal. The melting point is 37-38°C, the boiling point is 159-162°C (0.133kPa), and the refractive index (nD20) is 1.5299. Its hydrochloride ([1786-81-8]) is a white crystalline powder.

melting point

167-168°C. Soluble in water and ethanol, slightly soluble in chloroform. The taste is sour and bitter, and it is odorless.

use

local anesthetic. The drug effect of this product is better than that of procaine, and the strength and speed of local anesthesia are similar to those of lidocaine, but the action time is longer, the toxicity is less, and the accumulation is less due to fast metabolism. It is suitable for epidural anesthesia, conduction anesthesia and infiltration anesthesia, etc.

production method

O-toluidine is condensed with α-bromopropionyl bromide and then reacted with propylamine to obtain prilocaine.