Nilotinib Hydrochloride Anhydrous
Nilotinib hydrochloride anhydrous
CAS NO.:923288-95-3
Purity:99%
Use:agonist of serotonin-5HT1A receptor and an antagonist of the 5-HT2A receptor
Description
Nilotinib hydrochloride anhydrous
Products Description
Nilotinib Hydrochloride Anhydrous is the hydrochloride salt of nilotinib, an orally bioavailable aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. Designed to overcome imatinib resistance, nilotinib binds to and stabilizes the inactive conformation of the kinase domain of the Abl protein of the Bcr-Abl fusion protein, resulting in the inhibition of the Bcr-Abl-mediated proliferation of Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) cells. This agent also inhibits the receptor tyrosine kinases platelet-derived growth factor receptor (PDGF-R) and c-kit, a receptor tyrosine kinase mutated and constitutively activated in most gastrointestinal stromal tumors (GISTs). With a binding mode that is energetically more favorable than that of imatinib, nilotinib has been shown to have an approximately 20-fold increased potency in kinase and proliferation assays compared to imatinib.
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Synonyms: |
Nilotinib hydrochloride anhydrous;Nilotinib hydrochloride;4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}benzamide hydrochloride (1:1);AMN-107 HCl;Nilotinib hydrochloride anhydrou;Nilotinib hydrochloride anhydrous USP/EP/BP |
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CAS: |
923288-95-3 |
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MF: |
C28H23ClF3N7O |
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MW: |
565.99 |
Nilotinib hydrochloride anhydrous Usage And Synthesis
Nilotinib Hydrochloride might be useful in treatment of chronic myelogenous leukemia. It is a COVID19-related research product.
Package:
Package
1.PE 2 layers in side,aluminium foil bag outside
2.mg,g,2g, kg etc as customers'requirement
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Brief Introduction
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Jinan Jianfeng Chemical Co., Ltd. is a company headquartered in Jinan, China, which is specialized in the development, production and sales of pharmaceutical intermediates, APIs (active pharmaceutical ingredients), cosmetic raw materials and fine chemicals. The company has a state-of-the-art manufacturing facility and R&D center equipped with advanced technology and equipment to ensure high-quality products. Jinan Jianfeng Chemical Co., Ltd. has built a strong reputation in the industry with its dedication to quality, innovation and customer service. The company is committed to providing customers with safe and effective products that meet the highest quality standards and compliance.
Jinan Jianfeng Chemical specializes in providing raw materials for cosmetics, raw materials for analgesics, raw materials for antidepressants, raw materials for nootropic drugs, and various pharmaceutical intermediates. We continue to research and innovate, and provide our customers with high-quality and cheap products and high-quality services.
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