Apixaban API Powder

Apixaban Powder CAS 503612-47-3

The chemical name of apixaban is 1-(4-methoxyphenyl)-7-oxo-6[4-(2-oxopiperidin-1-yl)phenyl]-4,5 ,6,7-Tetrahydro-1H-pyrazole[3,4-c]pyridine-3-carboxamide, molecular formula is C25H25N5O4, molecular weight is 459.49700, density is 1.42g/cm3, boiling point is 770.468ºC at 760 mmHg, flash The point is 419.764ºC and the refractive index is 1.705. Clinically used in adult patients undergoing elective hip or knee replacement for the prevention of venous thromboembolic events (VTE).

What is Apixaban?

Apixaban is a highly selective, reversible, and direct inhibitor of Human Factor X and Rabbit Factor X with Ki of 0.08 nM and 0.17 nM, respectively. Apixaban exhibits a high degree of potency, selectivity, and efficacy on Factor X with Ki of 0.08 nM and 0.17 nM for Human Factor X and Rabbit Factor X, respectively. In vitro, Apixaban prolongs the clotting times of normal human plasma with theconcentrations (EC2x) of 3.6 μM, 0.37 μM, 7.4 μM, and 0.4 μM, which are required respectively to double the prothrombin time (PT),modified prothrombin time (mPT), activated partial thromboplastin time (APTT) and HepTest. Besides, Apixaban shows the highestpotency in human and rabbit plasma, but less potency in rat and dog plasma in both the PT and APTT assays.

Function and Application

A key component in helping our customers be first to market is a responsive supply chain. We achieve this by making sure that all our facilities are operating efficiently and to the latest standards of quality, safety, and productivity. A strong interconnect between business and factories allows for a quick reaction to dynamic market changes, so that we can avert shortages and meet sudden surges in demand.

Apixaban is an anticoagulant used to reduce the risk of stroke and systemic embolism in patients with non valvular atrial fibrillation.
A key component in helping our customers be first to market is a responsive supply chain. We achieve this by making sure that all our facilities are operating efficiently and to the latest standards of quality, safety, and productivity. A strong interconnect between business and factories allows for a quick reaction to dynamic market changes, so that we can avert shortages and meet sudden surges in demand.
Apixaban is a selective inhibitor of FXa. It does not require antithrombin III for antithrombotic activity. Apixaban inhibits free and clot-bound FXa, and prothrombinase activity. Apixaban has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting FXa, apixaban decreases thrombin generation and thrombus development

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