DL-Mevalonolactone
CAS 674-26-0
Sample is Available
Top quality and best price
COA, HPLC, MSDS available
Certificate: ISO,CTC,SGS,CQC
Place of Origin: Shandong, China
Description
DL-Mevalonolactone is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. It induces depolarization and swelling, decreases NADPH content and aconitase (ACO) activity, and increases malondialdehyde (MDA) production in calcium-loaded rat brain mitochondria. DL-Mevalonolactone reverses decreases in glucose uptake induced by simvastatin (Item Nos. 10010344 | 10010345) in L6 myotubes. Tissue levels and urinary excretion of DL-mevalonolactone are increased in patients with mevalonic aciduria, a disorder characterized by a deficiency in mevalonic kinase activity.
Application:
-Mevalonolactone is used to:
study the effect of statin on the prenylation of Ras and Rho GTPases
analyse the isoprenoid biosynthesis pathways in Listeria monocytogenes
study the the effects of statins on proliferation and migration of HUVECs (HGF-induced human umbilical vein endothelial cells)
| Melting point | 28 °C(lit.) |
| Boiling point | 145-150 °C5 mm Hg(lit.) |
| alpha | -1.0~+1.0°(20ºC/D)(c=5, C2H5OH) |
| density | 1.1066 (rough estimate) |
| refractive index | n20/D 1.473(lit.) |
| Fp | >230 °F |
| storage temp. | -20°C |
| solubility | (Sparingly), DMSO (Slightly), |
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